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The objectives of this work are a ; to introduce both undergraduate and postgraduate students into the regulatory affairs on veterinary medicines, b ; to stimulate the regular searching and use of the information from Official Regulatory Agencies by clinical students and veterinary professionals and c ; to facilitate acceding and understanding of the documents through novel learning material. The contents from Regulatory Guides and Directives, Technichal Specifications, Formularies, Press Releases, Annual Reports, Working Programmes and other related documents, created both by the EMEA European Medicines Agency ; and AEMPS Agencia Espaola de Medicamentos y Productos Sanitarios ; , have been compiled, translated, transcribed and interpreted. The results have been incorporated into a Clinical Bulletin and a Virtual Seminar developed in the "Campus Virtual" of the Complutense University of Madrid. Furthermore, the Virtual Seminar also includes links to other information sources, which facilitates additional searching, and an interactive forum, which favours the exchange of opinions between professors and students. These didactic materials represent excellent tools for the implementation of novel educational models based on the acquisition of competencies and centred in learning, in opposition to models only based on teaching. Thus, it can be implemented during problem-based learning PBL ; classes, clinical sessions and tutorial works of Pharmacology related subjects in Veterinary and in other Health Science curricula. Currently, only didactic material has been elaborated; during the next two academic courses it will be tried out in the Veterinary Faculty and its possible impact in the teaching of Pharmacology will be evaluated and decadron.
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Attempt to measure their potential effects. These different methods and their advantages and disadvantages are discussed here.8689 Zelen suggested a design in which patients are randomised to treatment arms before giving consent to the study, and efforts are made to ensure that the numbers changing arms are minimised.89 Consent is not sought from those receiving usual care. These participants are assumed to be at disadvantage by taking part, and outcome measures are limited to information usually recorded in medical records. The advantage of this design is that patients in the control group are not disappointed as they are not aware that they could have received the experimental treatment, removing this possible source of bias. However, this design is rarely used as a result of concerns about consent, and differential dropout rates occurring between the two groups as a result of different levels of information being given to participants in the two groups. A partially randomised design has been suggested by Brewin and Bradley, and represents the preferred design in the majority of studies conducted on issues relating to preference.90 Patients who express strong treatment preferences are allowed their desired treatment, while those who do not have strong views are randomised conventionally between the treatments available in the study. Both groups are followed up using the study outcome measures. However, the preference arms cannot be compared directly with the randomised arms, as baseline differences associated with preference may confound the effects of preference on outcome.91 Therefore, at least one analysis needs to be a comparison between the two randomised arms alone, and analyses that include the non-randomised groups have to be treated as observational studies with known confounding factors adjusted for in the analysis. Improvements have been suggested by Torgerson and colleagues, who recommended describing these confounders more precisely by eliciting the strength and direction of patient preferences before randomisation, 86 and by Olschewski and Scheurlen, who suggested that an analysis using randomisation status as a covariate might be helpful.92 Rucker proposed an alternative approach, in which randomisation was separated into two stages.87 In the first stage all patients are randomly allocated to one of two groups, the random group and the option group. At the second stage, patients in the random group are randomised a second time to the two treatment.
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Rapid behavioural effects of glucocorticoids Barsy Boglrka, Mikics va, Haller Jzsef Dept. of Behavioural Neurobiology, Inst. of Experimental Medicine, Hung. Acad. Sci., Budapest barsy koki.hu Glucocorticoid hormones are released from the adrenal gland in response to a number of physical and psychosocial challenges and modulate behavioural responses through various mechanisms. The variety of behaviours affected in different situations raise, however, questions regarding the specificity and roles of glucocorticoids in controlling behaviour. Earlier we demonstrated that corticosterone injection enhanced territorial aggression in a resident-intruder test of rats very rapidly within 2-7 min via non-genomic mechanisms. To elucidate the specificity and context dependency of this rapid behavioural effect, in the current study we assessed the acute behavioural consequences of glucocorticoids in non-social challenging situations and in a more complex social setting that approaches the natural situation of rats. As non-social challenging situations, we assessed the rapid behavioural effects of glucocorticoids in the elevated plus-maze EPM ; test, which measures three different kinds of behavioural responses: locomotion, anxiety-like behaviours, and risk assessment. The acute inhibition of glucocorticoid synthesis decreased risk assessment, but did not affect locomotion and anxiety-like behaviours. Corticosterone administration increased risk assessment, without affecting locomotion and anxiety-like behaviours. Moreover, plasma corticosterone levels measured immediately after testing strongly correlated with the intensity of risk assessment. The effects of corticosterone were rapid, as occurred even when the hormone was injected 2 min before behavioural testing. In addition, the effect was resistant to protein synthesis inhibition. These data demonstrate that glucocorticoids are able to increase specifically risk-assessment behaviours by nongenomic mechanisms novelty-related, non-social challenging situations. The acute effects of glucocorticoids were also investigated in a social setting, in which three individually marked and unfamiliar male rats were placed into a cage for 15 days. At the end of this period the acute consequences of corticosterone injection were investigated. Corticosterone injected animals exhibited more aggressive interactions compared to untreated and vehicle injected animals. Our results suggest that glucocorticoids are able to induce specific and context dependent behavioural adjustments to meet immediate requirements set by the challenge.
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